Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2004-12-01
2008-09-16
Witherspoon, Sikarl A (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C560S121000, C514S530000, C514S573000
Reexamination Certificate
active
07425651
ABSTRACT:
The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers.
REFERENCES:
patent: 5118711 (1992-06-01), Wilson et al.
patent: 5436226 (1995-07-01), Lulai et al.
patent: 6114284 (2000-09-01), Fujisawa et al.
patent: 6469061 (2002-10-01), Flescher et al.
patent: 2002/0173470 (2002-11-01), Flescher et al.
patent: 04-041414 (1992-02-01), None
patent: 4-41414 (1992-02-01), None
patent: 10-29935 (1998-02-01), None
patent: WO 02/080890 (2002-10-01), None
Derwent publications Ltd., London, class B05, AN 1998-163664, xp002203872.
Basaria et al, “Clinical review 138, anabolic-androgenic steroid therapy in treatment of chronic diseases”, Journal of clinical endocrinology and metabolism, 86(11):5108-5117, Nov. 2001.
Dangl et al., “Death don't have no mercy: cell death programs in plant-microbe interactions”, The Plant Cell, vol. 8, Oct. 1996, p. 1793-1807.
Dermastia, Marina et al., “the effects of a plant growth regulator, jasmonic acid, on some mammalian fibroblast cell lines” Acta Pharm. (Zagreb) 1992, 42(4), 347-50 XP001085225.
Farmer et al., “Interplant communication: Airborne Methl Jasmonate Induces Synthesis of Proteinase Inhyibitors Plant Leaves”, Proc. Natl. Acad. Sci. USA, vol. 87, Oct. 1990, p. 7713-7716.
Fingrut O. et al., “Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells”, Bios. Infor. Service, Philadelphia, PA, US, XP000185234, 2002, Apr. 2002, Accession No. 200200324956 & Leukemia (Basingstoke), vol. 16, No. 4, Apr. 2002. p. 608-616.
Gorospe et al., “Inhibition of G1 Cyclin-Dependent Kinase Activity. . . ”, Molecular and Cellular Biology, Mar. 1996, p. 762-770.
Ishii, Y. et al: “Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones”, Leukemia, 18(18), 1413-1419, 2004 XP002328125.
Kiyota, Hiromasa et al : “(.+−.)-Methyl 11-fluorojasmonate as a designed antimetabolite of methyl jasmonate: synthesis and plant growth regulator activity” XP002328126 & Nippon Noyaku Gakkaishi, 26(1), 96-99, 2001.
Lidija Klampfer et al., “Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines”, Blood, vol. 93, No. 7 Apr. 1, 1999, p. 2386-2394.
Mittler et al., “Sacrifice in the face of foes: pathogen-induced programmed cell death in plants”, Trends in Microbiology, vol. 4, No. 1, Jan. 1996, p. 10-15.
Nakaguchi, Osamu et al : “Hair growth stimulants containing dehydrodihydrojasmonic acid lower alkyl esters”, XP002328128, 1992.
Okano et al., Chemical Abstracts, vol. 127, #200188v, 1997.
Porter et al., “Emerging roles of caspass-3 in Apoptosis”, Cell Death and differentiation, 1999, p. 99-104.
Ryals et al., “Systemic Acquired Resistance”, The Plant Cell, vol. 8, Oct. 1996, p. 1809-1819.
Schierle K et al., “Homologues of Dihydro-12-oxo-phytodienoic acid and jasmonic acid by mixed kolbe electrolysis”, Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 37, No. 48, Nov. 25, 1996, p. 8715-8718, XP004068758.
Schwenger et al, “Cell-Type-Specific Activation Of C-Jun N-Terminal Kinase By Salicylates”, J. Of Cellular Physiology, 179, 1999, p. 109-114.
Schwenger et al., “Sodium salicylate induces apoptosis via p38 mitogen-activated. . . ”, Proc. Natl. Acad. Sci USA, 1997, p. 2869-2873.
Seiki et al., Chemical abstracts, vol. 126, #196471h, 1998.
Ward, Kerry et al : “The induction of proteinase inhibitor II by jasmonates” XP002328127, accession No. 1997 & Proceeding of the plant growth regulator society of America, 23RD, 291-294, 1996.
Willingham “Cytochemical methods for the detection of apoptosis”, The J. Of Histochemistry & Cytochemistry, vol. 47, p. 1101-1109, 1999.
Torii, Kousuke et al., “Evaluation of antiandrogen effect using SC-3 cells”, Database accession No. 127:200188 XP002203871 & Nippon Koshohin Kagakkaishi (19970, 21(2), 97-102.
Y. Ishii et al., “Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones”, Leukemia (2004) 18, 1413-1419.
H. Kiyota et al., “(+)-Methyl II-Fluorojasmonate as a Designed Antimetabolite of Methyl Jasmonate: Synthesis and Plant Growth Regulatory Activity”, J. Presticide Sci. (2001) 26, 96-99.
Chinese Office Action (for the National Phase of the PCT Application) issued May 16, 2008.
Flescher Eliezer
Kashman Yoel
Reischer Dorit
Shimony Shiri
Browdy and Neimark
Ramot at Tel-Aviv University Ltd.
Witherspoon Sikarl A
LandOfFree
Jasmonate derivative compounds, pharmaceuticals compounds... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Jasmonate derivative compounds, pharmaceuticals compounds..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Jasmonate derivative compounds, pharmaceuticals compounds... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3985844