Isoxazoline and isoxazole fibrogen receptor antagonists

Details Isoxazoline and isoxazole fibrogen receptor antagonists Isoxazoline and isoxazole fibrogen receptor antagonists

1997-11-25

2000-09-05

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142368, 514269, 514307, 514326, 514340, 514365, 514378, 514379, 514380, 544 60, 544111, 544137, 544140, 544297, 544298, 544322, 544333, 546141, 546143, 546209, 546275, 548146, 548240, 548243, 548248, A61K 3154, A61K 31445, C07D26102, C07D21700

Patent

active

061143286

ABSTRACT:
This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

REFERENCES:
patent: 4267186 (1981-05-01), Knops et al.
patent: 4283544 (1981-08-01), Jautelat et al.
patent: 4358598 (1982-11-01), Jautelat et al.
patent: 5039805 (1991-08-01), Alig et al.
Phillips et al. Cell (1991) 65, 359-362.
Hartman et al. J Mod Chem (1992) 35 4640-4642.
Alig et al. J Med Chem (1992) 35 4393-4407.

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