Isoxazole derivatives

Details Isoxazole derivatives Isoxazole derivatives

1997-02-26

1999-10-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548241, 548242, 548110, 544127, 544133, 546116, 546198, C07D26120, A61K 3142

Patent

active

059655917

ABSTRACT:
An isoxazole compound having the following formula: wherein R.sup.1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R.sup.2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.

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patent: 5750542 (1998-05-01), Villalubos et al.
patent: 5856503 (1999-01-01), Aebi et al.
T. Vitali, F. Mossini, G. Bertaccini and M. Impicciatore, "Proprieta Biologiche Di Composti 1,2-Benzisotiazolici", (1968), 1081-1096, Farmaco., Ed. Sci., 23 and English-language abstract thereof (CA, 70:37702).
T. Vitali, E. Gaetani, P. Mantovani and A. Agosti, "Proprieta Biologiche Di Composti 1,2-Benzistiazolici", (1969), 440-448, Farmaco., Ed. Sci., 24 and English-language abstract thereof (CA 71:49831).

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