Isoquinolines having adenosine uptake inhibitor activity

Details Isoquinolines having adenosine uptake inhibitor activity Isoquinolines having adenosine uptake inhibitor activity

1995-04-28

1997-08-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514248, 514267, 514245, 544284, 544237, 544250, 544212, 544234, 544233, 544247, 544245, C07D40114, A61K 31445, A61K 31505, A61K 3150

Patent

active

056589174

ABSTRACT:
The present invention relates to an adenosine uptake inhibitor and an agent for the myocardium protection or the prevention or treatment of inflammatory edema, comprising a 1,2,3,4-tetrahydro-2,4-dioxoquinazoline derivative represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, alkenyl, or substituted or unsubstituted aralkyl; R.sup.2, R.sup.3, R.sup.4, and R.sup.5 independently represent hydrogen, halogen, amino, mono- or di(lower alkyl)amino, lower alkanoylamino, nitro, cyano, substituted or unsubstituted lower alkyl, hydroxy, lower alkoxy, lower alkylthio, carboxy, lower alkoxycarbonyl, lower alkanoyl, aralkyloxy, or lower alkanoyloxy; R.sup.6, R.sup.7, R.sup.8, and R.sup.9 independently represent hydrogen, hydroxy, substituted or unsubstituted lower alkoxy, or aralkyloxy, or any adjoining two of them are combined to form methylenedioxy; R.sup.10 represents hydrogen or lower alkyl; and Y and Z independently represent N or C--R.sup.11 (wherein R.sup.11 represents hydrogen, substituted or unsubstituted lower alkyl, or halogen),
or a pharmaceutically acceptable salt thereof as an active ingredient.

REFERENCES:
patent: 4166117 (1979-08-01), Vincent et al.
patent: 4668683 (1987-05-01), Takai et al.
patent: 4680296 (1987-07-01), Manoury et al.
patent: 5504088 (1996-04-01), Sugimoto et al.
Nomoto, Y. et al., Chem. Pharm. Bull., vol. 38, No. 6 (1990) 1591-95. Month of publication not provided.
Young, M.A. et al. Am. J. Physiol., 261, H1570-H1577 (1991). Month of publication not provided.
Dorion, M. et al. J. Cardiovasc. Pharmacol. 19, 69-77 (1992). Month of publication not provided.
Remington's Pharm. Sci., (Phila. Coll. Pharm., Phila. (1992) 1286-1292. Month of publication not provided.

Affiliated with

Also associated with

Rating

Isoquinolines having adenosine uptake inhibitor activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isoquinolines having adenosine uptake inhibitor activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoquinolines having adenosine uptake inhibitor activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1105032