Isolation of neurotrophins from a mixture containing...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

Reexamination Certificate

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C530S324000, C530S350000, C530S412000, C530S416000, C530S417000, C435S069100, C435S069400, C435S070100, C435S071100

Reexamination Certificate

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06953844

ABSTRACT:
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable misprocessed, misfolded, size, glycosylated, or charge forms. Compositions of neurotrophins, including mature NGF, substantially free of these variants are also provided.

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