Isolated, tyrosinase derived peptides and uses thereof

Details Isolated, tyrosinase derived peptides and uses thereof Isolated, tyrosinase derived peptides and uses thereof

1994-02-28

1996-06-25

Budens, Robert D.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C07K 706, A61K 3808

Patent

active

055300960

ABSTRACT:
The invention relates to the identification of complexes of human leukocyte antigen molecules and tyrosinase derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.

REFERENCES:
patent: 4898814 (1990-02-01), Kwon
Roitt et al., Immunology, Moshy-Yearbook, St. Louis, Mo., pp. 6.10-6.11, 1993.
Brichard, et al, "The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas", J. Exp. Med. 178: 489-495 (1993).
Coullie, et al, "Genes Coding For Tumor Antigens Recognized by Human Cytolytic T. Lymphocytes", J. Immunotheray 14: 104-109 (1993).
Slingluff, et al, "Recognition of Human Melanoma Cells by HLA-A2.1 Restricted Cytotoxic T Lymhocytes As Mediated By At Least Six Shared Peptide Epitopes", J. Immunol. 150(7): 2955-2963 (Apr. 1, 1993).
Barinaga, "Getting Some `Backbone`: How MHC Binds Peptides" Science 257: 880-881 (Aug. 14, 1992).
Falk, et al, "Allele Specific Motifs revealed by sequencing of self-peptides eluted from MHC molecules", Nature 351: 290-296 (May 23, 1991).
Wolfel, et al, "Lysis of Human Melanoma Cells by Autologous Cytolytic T Cells Clones", J. Exp. Med. 170: 797-810 (Sep. 1989).

Affiliated with

Also associated with

Rating

Isolated, tyrosinase derived peptides and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated, tyrosinase derived peptides and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated, tyrosinase derived peptides and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2189824