Irreversible HIV protease inhibitor having an anti-aids activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549552, 549523, A01N 4320, A01N 3134

Patent

active

057734682

ABSTRACT:
The present invention relates to a novel compound of formula (I) and pharmaceutically acceptable salts, hydrates and solvates thereof which is an irreversible HIV protease inhibitor; a process for the preparation thereof; and a pharmaceutical composition containing the compound as an active ingredient which is useful for treating or preventing diseases caused by HIV infection. ##STR1##

REFERENCES:
Henderson et al., J. Virol., 62, 2597, Feb. 1988.
Moelling et al., FEBS Letter, 261, 373, Apr. 1990.
Pal et al., Proc. Natl. Aca. Sci., 85, 9283, Jun. 1988.
Grant et al., Bioorg. Med. Chem Letter, 2, 1441, Mar. 1992.

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