Ionene polymers and their use as antimicrobial agents

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Nitrogen heterocycle

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S078100, C424S402000, C424S070120, C424S422000, C528S423000

Reexamination Certificate

active

06955806

ABSTRACT:
Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.

REFERENCES:
patent: 3641034 (1972-02-01), Simon
patent: 3652149 (1972-03-01), Rogers
patent: 3770476 (1973-11-01), McKay
patent: 3874870 (1975-04-01), Green et al.
patent: 3923973 (1975-12-01), Green et al.
patent: 3929990 (1975-12-01), Green et al.
patent: 3931319 (1976-01-01), Green et al.
patent: 3946035 (1976-03-01), Jacquet et al.
patent: 3961042 (1976-06-01), Green et al.
patent: 3966906 (1976-06-01), Schultze et al.
patent: 3988158 (1976-10-01), Muramatsu et al.
patent: 4025617 (1977-05-01), Green et al.
patent: 4025627 (1977-05-01), Green et al.
patent: 4025653 (1977-05-01), Green et al.
patent: 4027020 (1977-05-01), Green et al.
patent: 4113709 (1978-09-01), Quinlan
patent: 4157387 (1979-06-01), Benedict
patent: 4206295 (1980-06-01), Wagner et al.
patent: 4217429 (1980-08-01), Wagner et al.
patent: 4379137 (1983-04-01), Ehlers et al.
patent: 4506081 (1985-03-01), Fenyes et al.
patent: 4778813 (1988-10-01), Fenyes et al.
patent: 4898808 (1990-02-01), Tachibana et al.
patent: 4923619 (1990-05-01), Legros
patent: 4960590 (1990-10-01), Hollis et al.
patent: 4980067 (1990-12-01), Hou et al.
patent: 5128100 (1992-07-01), Hollis et al.
patent: 5142002 (1992-08-01), Metzner
patent: 5149524 (1992-09-01), Sherba et al.
patent: 5256420 (1993-10-01), Tsao et al.
patent: 5283316 (1994-02-01), Dominguez et al.
patent: 5300287 (1994-04-01), Park
patent: 5352833 (1994-10-01), Merianos
patent: 5419897 (1995-05-01), Drake et al.
patent: 5451398 (1995-09-01), Vigh
patent: 5575917 (1996-11-01), Konstantin et al.
patent: 5575993 (1996-11-01), Ward et al.
patent: 5616317 (1997-04-01), Nagase et al.
patent: 5637308 (1997-06-01), Del Corral et al.
patent: 5646205 (1997-07-01), Lee et al.
patent: 5668084 (1997-09-01), Unhoch et al.
patent: 5681862 (1997-10-01), Hollis et al.
patent: 5709976 (1998-01-01), Malhotra
patent: 5843865 (1998-12-01), Del Corral et al.
patent: 5866016 (1999-02-01), Jaquess et al.
patent: 6007803 (1999-12-01), Mandeville, III et al.
patent: 6016508 (2000-01-01), Chu et al.
patent: 6034129 (2000-03-01), Mandeville, III et al.
patent: 6123928 (2000-09-01), Sovak et al.
patent: 2001/0041485 (2001-11-01), Zhao et al.
patent: 2003/0021761 (2003-01-01), Fitzpatrick et al.
patent: 2048233 (1992-05-01), None
patent: 0366853 (1990-05-01), None
patent: 0411 111 (1990-08-01), None
patent: 0392492 (1990-10-01), None
patent: 1 546 809 (1979-05-01), None
patent: 59-217787 (1984-12-01), None
patent: 60-229025 (1985-11-01), None
patent: 60-229027 (1985-11-01), None
patent: 62-51138 (1987-03-01), None
patent: 62-62881 (1987-03-01), None
patent: 2000280622 (2000-10-01), None
patent: 476257 (1976-05-01), None
patent: WO 90/09405 (1990-08-01), None
patent: WO 94/14872 (1994-07-01), None
patent: WO 96/20737 (1996-07-01), None
patent: WO 98/02136 (1998-01-01), None
patent: WO 99/02621 (1999-01-01), None
patent: WO 99/55320 (1999-11-01), None
Jegal, et al., “Development of Polyion Complex Membranes for the Separation of Water-Alcohol Mixtures.I. Synthesis and Physical Properties of the Polycations Based on 1,3-Di (4-pyridyl) propane”, J. Appl. Polymer Science, 54: 65-72 (1994).
Jegal, et al., “Development of Polyion Complex Membranes for the Separation of Water-Alcohol Mixtures. III. Preparation of Polyion Complex Membranes Based on the k-Carrageenan for the Pervaporation Separation of Water-Ethanol”, J. Appl. Polymer Sci., 60:1177-1183 (1996).
Kanazawa, et al., “Polymeric Phosphonium Salts as a Novel Class of Cationic Biocides. IV. Synthesis and Antibacterial Activity of Polymers with Phosphonium Salts in the Main Chain”, J. Polymer Sci.; Part A: Polymer Chemistry 31:3031-3038 (1993).
Nohira, et al., “Synthesis of Poly(alkylenediphenylphosphonium bromide”, Kobunshi Ronbunshu, 31(6):391-394 (1974).
Rembaum, et al., “Interaction of Living Cells with Polyionenes and Polyionene-Coated Surfaces”, J.Biomed. Mater. Res. Symposium 8: 101-110 (1977).
Yi, et al., “The Synthesis and Reduction Behavior of Substituted Polypropylviologens”, Acta Scientiarum Naturalium Universitatis Sunyatseni No. 2: 30-36(1986).
Brown, A.E., “Overview of fungal infections in cancer patients,”Seminars in Oncology, 17(3) SUPPL 6:2-5 (1990) (Abstract).
Epstein, J.B., et al., “Prophylaxis of candidiasis in patients with leukemia and bone marrow transplants,”Oral Surg. Oral Med. Oral Path. Oral Radiol. and Endodontics, 81(3):291-296 (1996).
Gibson, J., et al., “Oral staphylococcal mucositis: A new clinical entity in orofacial granulomatosis and Crohn's disease,”Oral Surg. Oral Med. Oral Path. Oral Radiol. and Endodontics,89(2):171-176 (2000).
Mosca, D.A., et al., “IB-367, a protegrin peptide with in vitro and in vivo activites against the microflora associated with oral mucositis,”Antimicrobial Agents and Chemotherapy, 44(7):1803-1808 (2000).
Ferretti, G.A., et al., “Therapeutic use of chlorhexidine in bone marrow transplant patients: case studies,”Oral Surg. Oral Med., and Oral Pathol., 63(6):683-687 (1987).
Mulholland, B., et al., “The antimicrobial activity of protamine and polybrene,”J. Hosp. Infection, 10:305-307 (1987).
Kourai, H., et al., “The Antimicrobial Characteristics of Poly [dimethyliminio (polymethylene) chloride]s,”J. Antibact. Antifung. Agents, 22(9):519-530 (1994).
Database CA [Online] Chemical Abstracts Service, Columbus, OH. Nagase, Hiroshi et al., “Synergistic microbicide compositions and control of microorganisms with them,” (retrieved from STN). Accession No. 130:263534.
Database CA [Online] Chemical Abstracts Service, Columbus, OH. Nagase, Hiroshi et al., “Synergistic compositions and method for control of microorganisms in water systems using ionene polymers and metal ions,” (retrieved from STN). Accession No. 130-233638.
Database CA [Online] Chemical Abstracts Service, Columbus, OH. Koma, Hiroki et al., “Sterilization of the hands with solutions containing microbicidal vinyl copolymers,” (retrieved from STN). Accession No. 122:99309.
Database CA [Online] Chemical Abstracts Service, Columbus, OH. Koma, Hiroki et al., “Biofouling inhibitors for industrial aqueous systems” (retrieved from STN). Accession No. 113:120571.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ionene polymers and their use as antimicrobial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ionene polymers and their use as antimicrobial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ionene polymers and their use as antimicrobial agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3435913

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.