Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1993-11-29
1997-09-30
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 6, 424450, 424 851, 424 852, 436173, 436806, A61B 5055
Patent
active
056723342
ABSTRACT:
This application concerns novel agents comprising cationic or chemically basic metal chelators in association with hydrophilic carriers of anionic or chemically acidic saccharides, sulfatoids and glycosaminoglycans. In certain embodiments, the agents comprise metals and metal ions. Covalent and non-covalent chemical and physical means are described for stabilizing the binding of the metal chelators to the carriers. Novel non-covalently bound compositions are described which give uniquely high payloads and ratio of metal chelator to carrier, ranging from a low of about 15% metal chelator by weight, to a characteristic range of 70% to 90% metal chelator by weight. Specific embodiments are described comprising deferoxamine, ferrioxamine, iron-basic porphine, iron-triethylenetetraamine, gadolinium DTPA-lysine, gadolinium DOTA-lysine and gadolinium with basic derivatives of porphyrins, porphines, expanded porphyrins, Texaphyrins and sapphyrins as the basic or cationic metal chelators, which are in turn, bound to acidic or anionic carriers, including one or more of acidic or anionic saccharides, and including sulfated sucrose, pentosan polysulfate, dermatan sulfate, oversulfated dermatan sulfate, chondroitin sulfate, oversulfated chondroitin sulfate, heparan sulfate, beef heparin, porcine heparin, non-anticoagulant heparins, and other native and modified acidic saccharides and glycosaminoglycans.
Also disclosed are methods of enhancing in vivo imgages arising from induced magnetic resonance signals, methods of enhancing in vivo images in conjunction with ultrasound or X-rays and methods of obtaining in vivo body images utilizing radioisotope containing agents. Methods of treating vasular disease are also disclosed.
REFERENCES:
patent: 3158552 (1964-11-01), Gaeumann et al.
patent: 3957435 (1976-05-01), Adams et al.
patent: 3961038 (1976-06-01), Benes
patent: 4024073 (1977-05-01), Shimizu et al.
patent: 4115534 (1978-09-01), Ithakissios
patent: 4182330 (1980-01-01), Michaels
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4397867 (1983-08-01), Blake
patent: 4419365 (1983-12-01), McLachlan
patent: 4427808 (1984-01-01), Stol et al.
patent: 4432802 (1984-02-01), Harata et al.
patent: 4446126 (1984-05-01), Jordan
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4568536 (1986-02-01), Kronenthal et al.
patent: 4577636 (1986-03-01), Spears
patent: 4613616 (1986-09-01), Winston et al.
patent: 4619913 (1986-10-01), Luck et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4647447 (1987-03-01), Gries et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4683142 (1987-07-01), Zimmerman et al.
patent: 4689323 (1987-08-01), Mitra et al.
patent: 4703108 (1987-10-01), Silver et al.
patent: 4710493 (1987-12-01), Landsberger
patent: 4732864 (1988-03-01), Tolman
patent: 4738955 (1988-04-01), Landsberger
patent: 4745180 (1988-05-01), Moreland et al.
patent: 4804529 (1989-02-01), Bardy et al.
patent: 4863964 (1989-09-01), Hedlund et al.
patent: 4880008 (1989-11-01), Lauffer
patent: 4904479 (1990-02-01), Illum
patent: 4925678 (1990-05-01), Ranney
patent: 4957939 (1990-09-01), Gries et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 4986980 (1991-01-01), Jacobsen
patent: 5021236 (1991-06-01), Gries et al.
patent: 5021404 (1991-06-01), Folkman et al.
patent: 5023078 (1991-06-01), Halluin
patent: 5039529 (1991-08-01), Bergendal et al.
patent: 5108759 (1992-04-01), Ranney
patent: 5155215 (1992-10-01), Ranney
patent: 5288704 (1994-02-01), Ungheri et al.
patent: 5308617 (1994-05-01), Halluin
patent: 5427767 (1995-06-01), Kresse et al.
Ranney, "Drug Targeting to the Lungs" Biochemical Pharmacology, vol. 35, No. 7, pp. 1063-1069, 1986, published in Europe.
Lambe, et al., "Morphological stabilization of the glycocalyces of 23 strains of five Bacteroides species using specific antisera" Can. J. Microbiol., vol. 30, pp. 809-819, 1984, published in Canada.
Costerton, et al., "How Bacterial Stick" Scientific American, vol. 238:86, Jan. 1978, published in U.S.A.
Epenetos et al., "Monoclonal antibodies for imaging and therapy" Br. J. Cancer, 59:152-155, 1989, published in Europe.
Mayberry-Carson et al., "Bacterial Adherence and Glycocalyx Formation in Osteomyelitis Experimentally Induced with Staphylococcus aureus" Infection and Immunity, 43:825-833, Mar., 1984, published in U.S.A.
Jain, "Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies" Journal of the National Cancer Institute, 81:570-576, 1989, published in U.S.A.
Henneberry et al., "Immunocytochemical Localization of VP16-213 In Normal and Malignant Tissues" Cancer Letters, 37, 1987, pp. 225-233, published in Ireland.
Henneberry et al., "Light Microscope Visualization of Tissue and Tumour Distributions of Anti-Cancer Drugs Using Immunocytochemistry". Abstract #1931, Seventy-Ninth annual meeting of the American Association for Cancer Research May 25-28, 1988 Proceedings, Proceedings of AACR, vol. 29, Mar. 1988, p. 486, published in U.S.A.
Dvorak et al., "Identification and Characterization of the Blood Vessels of Solid Tumors That Are Leaky to Circulating Macromolecules" American Journal of Pathology, vol. 133, No. 1, Oct. 1988, published in U.S.A.
Weinstein et al., "Selected Issues in the Pharmacology of Monoclonal Antibodies" Site-Specific Drug Delivery, 1986:pp. 81-91, published in U.S.A.
Mahadoo et al., "Vascular Sequestration of Heparin" Thrombosis Research, vol. 12, pp. 79-90, 1977, published in Europe.
Engel et al., "Intestinal Absorption of Heparin Facilitated by Sulfated of Sulfonated Surfactants" Journal of Pharmaceutical Sciences, vol. 58, No. 6, Jun. 1969, pp. 706-710, published in U.S.A.
Smirnov et al., "Carrier-directed targeting of liposomes and erythrocytes to denuded areas of vessel wall" Proc. Natl. Acad. Sci. USA, vol. 83, pp. 6603-6607, Sep. 1986, published in U.S.A.
Ghitescu et al., "Specific Binding Sites for Albumin Restricted to Plasmalemmal Vesicles of Continuous Capillary Endothelium: Receptor-mediated Transcytosis" The Journal of Cell Biology, vol. 102, Apr. 1986, pp. 1304-1311, published in U.S.A.
Laurie et al., "Localization of Binding Sites for Laminin, Heparan Sulfate Proteoglycan and Fibronectin on Basement Membrane (Type IV) Collagen" J. Mol. Biol., 1986:189, pp. 205-216, published in Europe.
Williams et al., "Micropinocytic ingestion of glycosylated albumin by isolated microvessels: Possible role in pathogenesis of diabetic microangiopathy" Proc. Natl. Acad. Sci, USA, vol. 78, No. 4, pp. 2393-2397, Apr. 1981, published in U.S.A.
Glimelius et al., "Binding of Heparin on the Surface of Cultured Human Endothelial Cells" Thrombosis Research, 1978, vol. 12, No., 5, pp. 773-782, published in Europe.
Jaques, "Drug Prophylaxis in Atherosclerosis" Artery, 14(4):209-215, 1987, place of publication is uncertain, possibly Canada.
Parsons et al., "Antibacterial Activity of Bladder Surface Mucin Duplicated in the Rabbit Bladder by Exogenous Glycosaminoglycan (Sodium Pentosanpolysulfate)" Infection and Immunity. vol. 27, No. 3., Mar. 1980, pp. 876-881, published in U.S.A.
Ryan et al., "New Substrates for the Radioassay of Angiotensin Converting Enzyme of Endothelial Cells in Culture" Tissue & Cell, 1978 10(3):555-562, publised in Europe.
Fransson, "Self-Association of Bovine Lung Heparan Sulphates Indentification and Characterization of Contact Zones" Eur. J. Biochem. 120, 251-255, 1981, published in Europe.
Jaques et al., "Intrapulmonary Heparin A New Procedure for Anticoagulant Therapy" The Lancet, Nov. 27, 1976, pp. 1157-1161, published in Europe.
Wick et al., "In Vivo Localization and Pathological Effects of Passively Transferred Antibodies to Type IV Collagen and Laminin in Mice" Clinical Immunology and Immunopathology, 23:656-665, 1982, published in U.S.A.
Lopes et al., "Presence of Laminin Receptors in Staphylococcus aureus" Science, vol. 229, Jul. 1985, pp. 275-277, published in U.S.A.
Holthofer et al., "Ulex europaeus I Lectin as a Marker for Vascular Endothelium in Human Tissues" Laboratory Investigation, vol. 47, No. 1, pp. 60-65, 19
Access Pharmaceuticals Inc.
Hollinden Gary E.
LandOfFree
Invivo agents comprising cationic metal chelators with acidic sa does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Invivo agents comprising cationic metal chelators with acidic sa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Invivo agents comprising cationic metal chelators with acidic sa will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2254973