Intracellular phospholipase A.sub.2 enzyme

Details Intracellular phospholipase A.sub.2 enzyme Intracellular phospholipase A.sub.2 enzyme

1993-01-13

1994-10-11

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 697, 4352402, 4353201, 435183, 435187, 530352, 536 232, C12N 920, C12N 500, C12N 900, C07H 1700

Patent

active

053546776

ABSTRACT:
The-invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.

REFERENCES:
Leslie et al. (1988) Biochimica et Biophysica Acta vol. 963: 476-492.
Grantham et al. (1981) Nucleic Acid Research vol. 9: r43-r74.
Suggs et al. (1981) PNAS vol. 78: pp. 6613-6617.

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