Interleukin-3 (IL-3) variant fusion proteins, their recombinant

Details Interleukin-3 (IL-3) variant fusion proteins, their recombinant Interleukin-3 (IL-3) variant fusion proteins, their recombinant

1994-02-04

1998-04-14

Fitzgerald, David L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

424 851, 424 852, 42419511, 435 695, 435 6952, 435 697, 536 234, 536 235, 536 2352, 530351, A61K 3819, A61K 3820, C12N 1562, C07K 1454

Patent

active

057388490

ABSTRACT:
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.

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