Insulin receptor substrate

Details Insulin receptor substrate Insulin receptor substrate

1993-07-21

1997-04-15

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530352, 514 2, C07K 1447

Patent

active

056210752

ABSTRACT:
A purified protein that is identified herein as insulin receptor substrate 1 (IRS-1) is disclosed, as well as a method of purifying IRS-1 and a recombinant nucleic acid encoding it.

REFERENCES:
patent: 5260200 (1993-11-01), Kahn et al.
Avruch et al., "Insulin-Stimulated Tyrosine Phosphorylation of the Insulin Receptor in Detergent Extracts of Human Placental membranes", J. Biol. Chem. 256:15162-15169, 1982.
Beguinot et al., "Differentiation-Dependent Phosphorylation of a 175,000 Molecular Weight Protein in Response to Insulin and Insulin-Like Growth Factor-1 in L6 Skeletal Muscle Cells", Endocrinology, vol. 125, No. 3, pp. 1599-1605, 1989.
Beguinot et al., "Phosphorylation of Insulin-Like Growth Factor I Receptor by Insulin Receptor Tyrosine Kinase in Intact Cultured Skeletal Muscle Cells", Biochem. 1988, 27, 3222-3228.
Bernier et al., "Insulin-Activated Tyrosine Phosphorylation of a 15-Kilodalton Protein in Intact 3T3-L 1 Adipocytes", Proc. Natl. Acad. Sci. USA, vol. 84, pp. 1844-1848, Apr. 1987.
Chou et al., "Human Insulin Receptors Mutated at the ATP-Binding Site Lack Protein Tyrosine Kinase Activity and Fail to Mediate Postreceptor Effects of Insulin", J. Biol. Chem., vol. 262, No. 4, pp. 1842-1847, Feb. 5, 1987.
Condorelli et al., "Insulin and Insulin-Like Growth Factor I (IGF I) Stimulate Phosphorylation of A M .sub.r 175,000 Cytoskeleton-Associated Protein in Intact FRTL5 Cells", J. Biol. Chem., vol. 264, No. 21, pp. 12633-12638, Jul. 25, 1989.
Cunningham et al., "The Complete Amino Acid Sequence of a .beta..sub.2 -Microglobulin", Biochem., vol. 12, No. 24, Nov. 20, 1973.
Cuatrecasas, "Affinity Chromatography and Purification of the Insulin Receptor of Liver Cell Membranes", Proc. Natl. Acad. Sci. USA, vol. 69, No. 5, pp. 1277-1281, May 1972.
Ellis et al., "Replacement of Insulin Receptor Tyrosine Residues 1162 and 1163 Compromises Insulin-Stimulated Kinase Activity and uptake of 2-Deoxyglucose", Cell, vol. 45, pp. 721-732, Jun. 6, 1986.
Freychet et al., "Insulin Receptors in the Liver: Specific Binding of [.sup.125 I] Insulin to the Plasma Membrane and its Relation to Insulin Bioactivity", Proc. Natl. Acad. Sci. USA, vol. 68, No. 8, pp. 1833-1837, Aug. 1971.
Goren et al., "The 180,000 Molecular Weight Plasma membrane Insulin Receptor Substrate is a Protein Tyrosine Phosphatase and is Elevated in Diabetic Plasma Membranes", vol. 180, pp. 463-469.
Heffetz et al., "H.sub.2 O.sub.2 Potentiates Phosphorylation of Novel Putative Substrates for the Insulin Receptor Kinase in intact Fao Cells", J. Biol. Chem., vol. 264, No. 17, pp. 10126-10132, Jun. 15, 1989.
Izumi et al., "Insulin-Like Growth Factor I Rapidly Stimulates Tyrosine Phosphorylation of a M.sub.r 185,000 Protein in Intact Cells", J. Biol. Chem., vol. 262, No. 3, pp. 1282-1287, Jan. 25, 1987.
Jacobs et al., "Isolation and Characterization of Genomic and cDNA Clones of Human Erythropoietin", Nature, vol. 313, No. 6005, pp. 806-810, Feb. 28, 1985.
Kadowaki et al., "Tyrosine Phosphorylation of Common and Specific Sets of Cellular Proteins Rapidly Induced by Insulin, Insulin-Like Growth Factor I, and Epidermal Growth Factor in an Intact Cell", J. Biol. Chem., vol. 262, No. 15, pp. 7342-7350, May 25, 1987.
Kahn et al., "The Insulin Receptor and the Molecular Mechanism of Insulin Action", J. Clin. Invest., vol. 82, pp. 1151-1156, Oct. 1988.
Kamps et al., "Identification of Multiple Novel Polypeptide Substrates of the v-src, v-yes, v-fps, v-ros, and v-erb B Oncogenic Tyrosine Protein Kinases Utilizing Antisera Against Phosphotyrosine", Oncogene, vol. 2, pp. 305-315, 1988.
Kaplan et al., "Common Elements in Growth Factor Stimulation and Oncogenic Transformation: 85 kd Phosphoprotein and Phosphatidylinositol Kinase Activity", Cell, vol. 50, pp. 1021-1029, Sep. 25, 1987.
Kasuga et al., "Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of its Own Receptor", Science, vol. 215, pp. 185-186; Jan. 8, 1982.
Kasuga et al., "Insulin Stimulates Tyrosine Phosphorylation of the Insulin Receptor in a Cell-Free System", Nature, vol. 298, pp. 667-669; Aug. 12, 1982.
Lau et al., "Phosphotyrosyl Protein Phosphatases", Biochem. J., vol. 257, pp. 23-36, 1989.
Levenson et al., "Insulin-Stimulated Protein Tyrosine Phosphorylation of Intact Cells Evaluated by Faint Two-Dimensional Gel Electrophoresis", J. Biol. Chem., vol. 264, No. 33, pp. 19984-19993, Nov. 25, 1989.
Madoff et al., "Insulin and Insulin-Like Growth Factor I Stimulate the Phosphorylation on Tyrosine of a 160 kDa Cytostolic Protein in 3T3-1 Adipocytes", Biochem. J., vol. 252, pp. 7-15, 1988.
Maegawa et al., "Insulin Receptors with Defective Tyrosine Kinase Inhibit Normal Receptor Function at the Level of Substrate Phosphorylation", J. Biol. Chem., vol. 263, No. 25, pp. 12629-12637, Sep. 5, 1988.
Meisenhelder et al., "Phospholipase C-.gamma. is a Substrate for the PDGF and EGF Receptor Protein-Tyrosine Kinases in vivo and in vitro", Cell, vol. 57, pp. 1109-1122, Jun. 30, 1989.
Moller et al., "A Naturally occurring Mutation of Insulin Receptor Alanine 1134 Impairs Tyrosine Kinase Function and is Associated with Dominantly Inherited Insulin Resistance", J. Biol. Chem., vol. 265, No. 25, pp. 14979-14985, Sep. 5, 1990.
Moller et al., "Detection of an Alteration in the Insulin-Receptor Gene in a Patient with Insulin Resistance, Acanthosis Nigricans, and the Polycystic Ovary Syndrome (Type A Insulin Resistance)", New Engl. J. Med., vol. 319, pp. 1526-1529, 1988.
Moller et al., "Insulin Resistance--Mechanisms, Syndromes, and Implications", The New England Journal of Medicine, vol. 325, pp. 938-948, 1991.
Morgan et al., "Acute Insulin Action Requires Insulin Receptor Kinase Activity: Introduction of an Inhibitory Monoclonal Antibody into Mammalian Cells Blocks the Rapid Effects of Insulin", PNAS, vol. 84, pp. 41-45, 1987.
Morrison et al., "Direct Activation of the Serine/Theonine Kinase Activity of Raf-1 Through Tyrosine Phosphorylation by the PDGF .beta.-Receptor", Cell, vol. 58, pp. 649-657, Aug. 25, 1989.
Odawara et al., "Human Diabetes Associated with a Mutation in the Tyrosine Kinase Domain of the Insulin Receptor", Science, vol. 245, pp. 66-68, Jul. 7, 1989.
Pang et al., "Purification of the Catalytically Active Phosphorylated Form of Insulin Receptor Kinase by Affinity Chromatography with O-Phosphotyrosyl-Binding Antibodies", Arch. of Biochem. and Biophysics, vol. 242, No. 1, pp. 176-186, Oct. 1985.
Rees-Jones et al., "An Endogenous Substrate for the Insulin Receptor-Associated Tyrosine Kinase", J. Biol. Chem., vol. 260, No. 7, pp. 4461-4467, Apr. 10, 1985.
Rosen et al., "Phosphorylation Activates the Insulin Receptor Tyrosine Protein Kinase", Proc. Natl. Adac. Sci. USA, vol. 80, pp. 3237-3240, Jun. 1983.
Rothenberg et al., "Purification and Partial Sequence Analysis of pp 185, the Major Cellular Substrate of the Insulin Receptor Tyrosine Kinase", Purification and Partial Sequence Analysis of PP185, The Major Cellular Substrate of the Insulin Receptor Tyrosine Kinase, vol. 266, pp. 8302-8311; 1991.
Shemer et al., "Insulin and Insulin-Like Growth Factor-I Stimulate a Common Endogenous Phosphoprotein Substrate (pp 185) in Intact Neuroblastoma Cells", J. Biol. Chem. vol. 262, No. 32, pp. 15476-15482, Nov. 15, 1987.
Suggs et al., "Use of Synthetic Oligonucleotides as Hybridization Probes: Isolation of Cloned cDNA Sequences for Human .beta..sub.2 -Microglobulin", Proc. Natl. Acad. Sci. USA, vol. 78, No. 11, pp. 6613-6617; Nov. 1981.
Sun et al., "Structure of the Insulin Receptor Substrate IRS-1 Defines a Unique Signal Transduction Protein", Nature, 352:73-77, 1991.
Taira et al., "Human Diabetes Associated with a Deletion of the Tyrosine Kinase Domain of the Insulin Receptor" Science 245:63-66, 1989.
White et al., "Characterization of an Endogenous Substrate of the Insulin Receptor in Cultured Cells", J. Biological Chemistry 262:9769-9777, 1987.
White et al., "Insulin Rapidly Stimulates Tyrosine Phosphorylation of a M.sub.r- 185,000 Protein in Intact Cells" Nature 318:183-186 1985.
White et al., "Mutation of the Insulin Receptor at Tyrosine 960 Inhibits Signal Transmiss

Affiliated with

Also associated with

Rating

Insulin receptor substrate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Insulin receptor substrate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Insulin receptor substrate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-361629