Insulin derivatives and pharmaceutical preparations containing t

Details Insulin derivatives and pharmaceutical preparations containing t Insulin derivatives and pharmaceutical preparations containing t

1990-12-20

1992-10-20

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 514866, A61K 3702, A61K 3726, C07K 740

Patent

active

051570211

ABSTRACT:
Insulin derivatives in which from two to four amino acid residues of positions, A4, A17, B13 and B21 comprise an uncharged side chain and pharmaceutical preparations containing these insulin derivatives. The disclosed insulin derivatives and preparations possess protracted insulin activity. The protracted insulin activity is relatively insensitive to tryptic activity.

REFERENCES:
patent: 3903068 (1975-09-01), Ruttenberg
patent: 4320196 (1982-03-01), Morihara et al.
patent: 4320197 (1982-03-01), Morihara et al.
patent: 5028586 (1991-07-01), Balschmidt
F. Marki et al., Hoppe-Seyler's Z. Physiol. Chem., Bd. 360. S. 1619-1632, 1979.
Daniel Levy, Biochimica et Biophysica Acta, 310 (1973), pp. 406-415.

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