Instantaneous radioiodination of rose bengal at room temperature

Details Instantaneous radioiodination of rose bengal at room temperature Instantaneous radioiodination of rose bengal at room temperature

1979-04-03

1981-11-03

Padgett,, Benjamin

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

422 61, 424 9, A61K 4900, A61K 4300, G01T 100, B65D 7100

Patent

active

042985919

ABSTRACT:
The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free .sup.125 I.sup.- is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.

REFERENCES:
patent: 3743713 (1973-07-01), Kato et al.
patent: 3928552 (1975-12-01), Winchell et al.
patent: 3959455 (1976-05-01), Ansari et al.
patent: 4028389 (1977-06-01), Wenzel et al.
Rabin et al., Int. J. Appl. Rad. Isotopes, 19, 361-367 (1968).
Serafini et al., J. Nucl. Med., 16, 629-632 (1975).
Ginzburg, Chem. Abstracts, vol. 79, No. 19, Nov. 12, 1973, Abstract #112910j.
Brousil et al., Chem. Abstracts, vol. 79, No. 5, Aug. 6, 1973, Abstract #29411b.

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