Inhibitors of tyrosine kinases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S252180, C514S275000, C544S122000, C544S295000, C544S331000

Reexamination Certificate

active

07569566

ABSTRACT:
The invention relates to compounds of formulawherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such a disease.

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patent: 02/46171 (2002-06-01), None
patent: 2004/002963 (2004-01-01), None
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Zimmermann et al., “Phenylamino-Pyrimidine (PAP)—Derivatives: A New Class of Potent and Highly Selective PDGF-Receptor Autophosphorylatin Inhibitors,” Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 11, pp. 1221-1226 (1996).
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Shibuya et al., “Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (fit) closely related to thefmsfamily,” Oncogene, vol. 5, pp. 519-524 (1990).
Dorsey et al., “Discovery of a Novel ABL Tyrosine Kinase Inhibitor That Selectively Induces Apoptosis of BCR-ABL-Positive Leukemic Cells,” Abstracts/Hematology, vol. 28(7), Suppl. 1, p. 49 (2000).
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