Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1996-04-11
1998-11-03
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
514533, 514563, 562450, 562451, 562455, C07C22900, A01N 3710
Patent
active
058311157
ABSTRACT:
The present invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, which are useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
REFERENCES:
Ortiz De Mantellano, P. R. et al., "Prenyl Substituted Cyclobutanones as Squalene Synthetase Inhibitors", Tetrahedron Letters, No. 46, pp. 4115-4118, printed in Great Britain by Pergamon Press, 1976.
Arendsen David L
Augeri David J.
Baker William R.
Fakhoury Stephen A
Fung Anthony K. L.
Abbott Laboratories
Crowley Steven R.
Killos Paul J.
Steele Gregory W.
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