Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

1996-11-15

1998-10-06

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546210, 544130, 5142358, A61K 31445, C07D40112

Patent

active

058176780

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 3038835 (1962-06-01), Endres et al.
patent: 5141851 (1992-08-01), Brown et al.
patent: 5238922 (1993-08-01), Graham et al.
patent: 5326773 (1994-07-01), deSolms et al.
patent: 5340828 (1994-08-01), Graham et al.
patent: 5352705 (1994-10-01), Deana et al.
patent: 5439918 (1995-08-01), deSolms et al.
patent: 5468733 (1995-11-01), deSolms et al.
patent: 5478934 (1995-12-01), Yuan et al.
patent: 5480893 (1996-01-01), Graham et al.
patent: 5486526 (1996-01-01), Durant et al.
patent: 5491164 (1996-02-01), deSolms et al.
patent: 5504212 (1996-04-01), deSolms et al.
patent: 5534537 (1996-07-01), Ciccarone et al.
patent: 5571835 (1996-11-01), Anthony et al.
patent: 5585359 (1996-12-01), Breslin et al.
J. of Biol. Chem., vol. 268, No. 11, pp. 7617-7620 (1993), by J. B. Gibbs, et al.
J. of Biol. Chem., vol. 266, No. 24, pp. 15575-15578 (1991), by J. L. Goldstein, et al.
J. of Biol. Chem., vol. 369, No. 44, pp. 27705-27714 (1994), by G. L. James, et al.
Science, vol. 260, pp. 1937-1942 (1993), by G. L. James, et al.
J. of Biol. Chem., vol. 270, No. 11, pp. 6221-6226 (1995), by G. L. James, et al.
Science, vol. 260, pp. 1934-1937 (1993), by N. E. Kohl, et al.
Proc. Natl. Acad. Sci. USA, Med. Sciences, vol. 91, pp. 9141-9145 (1994), by N. E. Kohl, et al.
Nature Medicine, vol. 1, No. 8 (1995), N. E. Kohl, et al.
Biochemistry, vol. 31, pp. 3800-3807 (1992), by D. L. Pompliano.
Cancer Research, vol. 55, pp. 5302-5309 (1995), by L. Sepp-Lorenzino, et al.
Exp. Opin. Ther. Patents, 5(12), pp. 1269-1285 (1995), by S. L. Graham.
U.S. application No. 08/143,943, Merck & Co., Inc.

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