Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-15
2011-03-15
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S253120, C514S252180, C514S333000, C514S339000, C544S122000, C544S295000, C544S363000, C546S256000, C546S275400
Reexamination Certificate
active
07906509
ABSTRACT:
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-III:wherein, variables R, X, Y1, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.
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Kennedy-Smith Joshua
Kondru Rama K.
Loe Bradley E.
Lou Yan
McIntosh Joel
Anderson Rebecca L
Johnston George W.
Kisko Jennifer
Otton Alicia L
Roche Palo Alto LLC
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