Inhibitor compounds of farnesyl-protein transferase and chemothe

Details Inhibitor compounds of farnesyl-protein transferase and chemothe Inhibitor compounds of farnesyl-protein transferase and chemothe

1996-03-06

1997-05-06

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435 52, 435136, 435146, 435147, 435148, 435169, 4352521, 4352526, 435822, C12N 120, C12P 106, C12P 3300

Patent

active

056270577

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. Furthermore, Actinoplanes sp. ATCC 55532 and Streptomces sp. ATCC 55550 are microorganisms which are capable of producing the disclosed compounds which are classified as carboxylic acid esters. In addition a method for preparing the compounds is disclosed which includes cultivating strain ATCC 55532 or strain ATCC 55550. The strains are independently capable of producing the carboxylic acid ester compounds.

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