Inhibition of phosphatidylinositol 3-kinase with viridin, demeth

Details Inhibition of phosphatidylinositol 3-kinase with viridin, demeth Inhibition of phosphatidylinositol 3-kinase with viridin, demeth

1997-02-25

1998-03-10

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3134

Patent

active

057261679

ABSTRACT:
Viridin, viridiol, demethoxyviridin, demethoxyviridiol, virone, and wortmannolone, and analogs thereof, are inhibitors of phosphatidylinositol 3-kinase. The compounds are particularly useful for inhibiting phosphatidylinositol 3-kinase in vertebrates and for treating phosphatidylinositol 3-kinase-dependent conditions, especially neoplasms, restenosis and atherosclerosis, and bone disorders in vertebrates.

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