Inhibition of cell motility, angiogenesis, and metastasis

Details Inhibition of cell motility, angiogenesis, and metastasis Inhibition of cell motility, angiogenesis, and metastasis

2011-01-18

2011-01-18

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S019200, C514S019300, C514S019400, C514S019500, C514S013300, C514S021500, C514S021600, C514S021700, C514S021800, C514S021900, C514S021910

Reexamination Certificate

active

07871981

ABSTRACT:
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. Also disclosed are methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer, for example, melanoma or prostate cancer, comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking blocks HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.

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