Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones

Details Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones

1993-08-04

1994-08-09

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549315, C07D30762, A61K 3134

Patent

active

053366875

ABSTRACT:
This invention relates to 4-phenoxy (and 4-substituted phenoxy)5-hydroxy-2(5H)-furanones of the formula: ##STR1## where Z is ##STR2## where R is H, halogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, trifluoromethyl, or ##STR3## and X is H, C.sub.1 -C.sub.8 alkyl, --O--C.sub.1 -C.sub.8 alkyl, or halogen; a process for their preparation, their use in the treatment of osteoporosis, and pharmaceutical compositions thereof.

REFERENCES:
patent: 3981857 (1976-09-01), Habu et al.
patent: 4516241 (1990-04-01), Haywood
patent: 4839385 (1989-06-01), Maullem et al.
patent: 4874782 (1989-10-01), Bonjouklian et al.
patent: 5026725 (1991-06-01), Hayward et al.
Chem. Abstr. 79(9): 53245w (Krawcynska et al., 1973).
Kharode, et al, J. Bone Min. Res. 2 (Suppl.), 358 (1987).

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