Tocols as adjuvant in vaccine

Details Tocols as adjuvant in vaccine Tocols as adjuvant in vaccine

1995-06-05

1997-09-16

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242831, A61K 3912, A61K 4500

Patent

active

056677847

ABSTRACT:
Oil based vaccines often cause serious local side effects at the site of administration and/or have a high viscosity which make said vaccines difficult to handle. Vaccines comprising as an adjuvant a stable emulsion of tocols in water do not display these undesired effects and induce good immune responses.

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A.C. Allison et al., Technogical Advances in Vaccine Development, 401-409 1988.
A. Franchini et al., La Clinica Veterinaria, 111:1-2:121-123, 1988.
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M. Afzal et al., Veterinary Immunology and Immunopathology, 7:293-304, 1984 .

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