Indolocarbazole derivatives, processes for their preparation and

Details Indolocarbazole derivatives, processes for their preparation and Indolocarbazole derivatives, processes for their preparation and

1994-01-21

1995-08-01

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514219, 514254, 540472, 540556, 544339, 544340, 548417, A61K 3140, A61K 31495, C07D24136, C07D24504

Patent

active

054380502

ABSTRACT:
New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.

REFERENCES:
patent: 4785085 (1988-11-01), Kaneko et al.
patent: 4808613 (1989-02-01), Kaneko et al.
patent: 4923986 (1990-05-01), Murakata et al.
Biochemical and Biophyscial Research Communications, Mar. 13, 1986 vol. 135, No. 2, 1986 pp. 397-402, Tamaoki et al., "Staurosporine, a Potent Inhibitor of Phospholipid/Ca++ Dependent Protein Kinase".
Tetrahedron Letters, vol. 24, No. 13 pp. 1441-1444, (1983), Hughes et al. "Synthesis of Arcyriaflavin R".
The Journal of Organic Chemistry, vol. 52 No. 7, Apr. 3, 1987, Joyce et al., "Synthesis of the Aromatic and Monosaccharide Moieties of Staurosporine", pp. 1177-1185.
Chemical Abstracts, 107:236750y, p. 796, (1987) Hirata, et al.

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