Indolesulphonamide-substituted dihydropyridines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514333, 546272, 546256, C07D40112, A61K 3144

Patent

active

052721612

ABSTRACT:
Indolesulphonamide-substituted dihydropyridines can be prepared by reaction of dihydropyridinecarboxylic acids with hydroxy-substituted indolesulphonamides, or by reaction of amino- or hydroxy-substituted dihydropyridines with indolesulphonamidecarboxylic acids. The indolesulphonamide-substituted dihydropyridines can be employed as active substances in medicaments for the treatment of cardiac, circulatory and thromboedabolic disorders.

REFERENCES:
Wade, Jr. Organic Chemistry p. 349, 1987.
G. V. R. Born, J. Physiol 162, 1962; p. 67.
Th. Green, "Protective Groups in Organic Synthesis," 1981, whole book.
E. L. Eliel, Stereochemistry of Carbon Compounds, 1962, whole book.

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