Indole-type derivatives as inhibitors of p38 kinase

Details Indole-type derivatives as inhibitors of p38 kinase Indole-type derivatives as inhibitors of p38 kinase

2007-07-03

2007-07-03

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S320000, C514S321000, C514S322000, C544S360000, C544S370000, C546S196000, C546S198000, C546S199000, C546S201000

Reexamination Certificate

active

10156997

ABSTRACT:
The invention is directed to methods to inhibit p38-α kinase using compounds of the formulaand the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, whereinrepresents a single or double bond;one Z2is CA or CR8A and the other is CR1, CR12, NR6or N wherein each R1, R6and R8is independently hydrogen or noninterfering substituent;A is —Wi—COXjY wherein Y is COR2or an isostere thereof and R2is hydrogen or a noninterfering substituent, each of W and X is a spacer of 2–6 Å, and each of i and j is independently 0 or 1;Z3is NR7or O;each R3is independently a noninterfering substituent;n is 0–3;each of L1and L2is a linker;each R4is independently a noninterfering substituent;m is 0–4;Z1is CR5or N wherein R5is hydrogen or a noninterfering substituent;each of l and k is an integer from 0–2 wherein the sum of l and k is 0–3;Ar is an aryl group substituted with 0–5 noninterfering substituents, wherein two noninterfering substituents can form a fused ring; andthe distance between the atom of Ar linked to L2and the center of the α ring is 4.5–24 Å.

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