Indole derivatives, salts thereof, and congestive heart failure

Details Indole derivatives, salts thereof, and congestive heart failure Indole derivatives, salts thereof, and congestive heart failure

1994-10-28

1996-04-23

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548430, 548431, A61K 3140, C07D491056

Patent

active

055103669

ABSTRACT:
An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

REFERENCES:
Bauta, W. E., "Cyclohexadienone Annulations of Aryl Carbene Complexes of Chromium: New Strategies for the Synthesis of Indole Alkaloids," J. Org. Chem, 1989, 54, 3249-3252.
Masaguer, C. F. "Alkylation of 3-Ethyl-2-Methyl-4-Oxo-4,5,6,7-Tetrahydroindole with Bromoesters: Benzenesulfonyl as Convenient Nitrogen Protecting Group," Heterocycles, vol. 34, No. 7, 1992, 1303-09.

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