Indole derivatives as MCP-1 receptor antagonists

Details Indole derivatives as MCP-1 receptor antagonists Indole derivatives as MCP-1 receptor antagonists

2006-01-10

2006-01-10

Desai, Rita (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S492000

Reexamination Certificate

active

06984657

ABSTRACT:
A compound of Formula I,wherein: R1is hydrogen, halo, methyl, ethyl or methoxy; R2is hydrogen, halo, methyl, ethyl or methoxy; R3is a halo group, lower alkyl, lower alkenyl, lower alkynyl, alkoxy, trifluoromethyl, nitro, cyano, trifluoromethoxy, C(O)R7, or S(O)nR7where n is 0, 1 or 2 and R7is an alkyl group; R4is a halo, trifluoromethyl, methylthio, methoxy, trifluoromethoxy or lower alkyl, lower alkenyl or lower alkynyl or COR8where R8is lower alkyl; R6is hydrogen, halo, lower alkyl, lower alkenyl, lower alkynyl or COR9where R9is lower alkyl; provided that when R1is hydrogen, halo or methoxy, R2is hydrogen, halo, methyl, ethyl or methoxy, R5and R6are both hydrogen, and one of R3or R4is not halo or trifluoromethyl; or a pharmaceutically acceptable salt or prodrug thereof. These compounds have useful activity for the treatment of inflammatory disease, specifically in antagonizing an MCP-1 mediated effect in a warm-blooded animal such as a human being.

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