Indole derivative having heterocycle and mono- or...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S350000, C546S113000, C548S469000

Reexamination Certificate

active

07612070

ABSTRACT:
There is provided a compound represented by the general formula (1):wherein Het represents an optional substituted heterocylic group A1and A2each independently represent —CH═, etc.; A3represents —CH2—, etc.; R1represents a 4-fluorophenyl group, etc.; R2represents an alkyl group; n represents 0, 1 or 2, provided that when A1and A2both are —CH═, A3represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.

REFERENCES:
patent: 2007/0238735 (2007-10-01), Garvey et al.
patent: 0535925 (1992-09-01), None
patent: 0846689 (1997-12-01), None
patent: 10-077266 (1998-03-01), None
patent: WO 96/06840 (1996-03-01), None
patent: WO 97/30030 (1997-08-01), None
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta et al. Advanced Drug Delivery Reviews 2001, 48, 3-26.
Brideau et al. Inflammation Research 1996, 45, 68-74.

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