Incorporation of a water-soluble active principle in a lipid

Details Incorporation of a water-soluble active principle in a lipid Incorporation of a water-soluble active principle in a lipid

1997-10-28

2000-01-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424401, 424439, A61K 9127

Patent

active

060175583

ABSTRACT:
To incorporate a water-soluble active principle in a stable lipidic phase, the water-soluble active principle is added with stirring in the presence of water to a fat containing a lecithin fraction low in phosphatidyl choline and the heterogeneous mixture obtained is dried to form a homogeneous micellar phase.

REFERENCES:
patent: 3701668 (1972-10-01), Morse
patent: 4999208 (1991-03-01), Lengerich
patent: 5084289 (1992-01-01), Shin
patent: 5284941 (1994-02-01), Colarow
Pharmacological and Chemical Synonyms, E. E. J. Marler, Ed., 6th ed., p. 361, 1976.
Textbook of Biochemistry with Clinical Correlations, T. M. Devlin, Ed., pp. 490-491, 1982.
Derwent Publications, database WPI, AN 88-087108& JP-A-63 036 792, Feb. 17, 1988 and Patent Abstracts of Japan, vol. 12, No. 248 (C-511), Jul. 13, 1988.
Derwent Publications, database WPI, AN 87-112992 and JP-A-62 059 287.

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