IN VITRO METHOD FOR DISASSEMBLY/REASSEMBLY OF PAPILLOMAVIRUS...

Details IN VITRO METHOD FOR DISASSEMBLY/REASSEMBLY OF PAPILLOMAVIRUS... IN VITRO METHOD FOR DISASSEMBLY/REASSEMBLY OF PAPILLOMAVIRUS...

2005-11-08

2005-11-08

Salimi, Ali R. (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S236000, C435S235100

Reexamination Certificate

active

06962777

ABSTRACT:
A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or “marker” DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.

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Sapp et al. J of General Virology, 1995, vol. 76, pp. 2407-2412.
Li et al. J of Virology, Apr. 1997, vol. 71, No. 4, pp. 2988-2995.
Touze et al. Nucleic Acid Research, 1998, vol. 26, No. 5, pp. 1317-1323.
Chen et al. 16thInternational Papillomavirus Conference, Sep. 5-6, 1997.

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