Surgery – Truss – Pad
Patent
1991-04-09
1992-11-24
Cohen, Lee S.
Surgery
Truss
Pad
204403, 204415, A61B 500
Patent
active
051654075
ABSTRACT:
Implantable enzymatic sensors (25, 43, 44) for biochemicals such as glucose are provided having an ideal size and geometry for optional long term implantation and linear responses over the concentration ranges of interest. The sensors (25, 43, 44) include an elongated body (10, 26, 46) supporting an indicating electrode section having an appropriate enzyme immobilized thereon to present an enzymatic indicating surface (21, 33, 54). A permeable synthetic polymer membrane (24, 42, 56) is applied over the sensor body (10, 26, 46) to protect the enzyme and regulate diffusion of analyte therethrough, to ensure linearity of sensor response. The sensors (25, 43) are of flexible design and can be implanted using a catheter. Alternately, the sensor (44) includes an internal indicating electrode body (46) housed within an apertured, hollow needle (48). A holder (66) affixed to the needle (48) allows for easy manipulation and implantation of the sensor (44).
REFERENCES:
patent: 3249103 (1966-05-01), Woodhouse
patent: 3726777 (1973-04-01), Macur
patent: 4545382 (1985-10-01), Higgins et al.
patent: 4671288 (1987-06-01), Gough
Updike et al., "The Enzyme Electrode", Nature, vol. 214, Jun. 1967, pp. 986-988.
Salkind et al., "Improving . . . Stability", Med. Inst., vol. 15, No. 2, Mar.-Apr. 1981, pp. 126-127.
Bindra Dilbir S.
Hill Brian S.
Reach Gerard
Sternberg Robert
Thevenot Daniel R.
Cohen Lee S.
The University of Kansas
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