Immunological adjuvant constituted by the p-amino-phenyl derivat

Details Immunological adjuvant constituted by the p-amino-phenyl derivat Immunological adjuvant constituted by the p-amino-phenyl derivat

1977-10-25

1980-01-22

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 93, 424177, 2601125R, A61K 3900, A61K 3748, A61K 3702, C07C10352

Patent

active

041850890

ABSTRACT:
The adjuvant is 2-(p-amino-phenyl-2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L- alanyl-D-isoglutamine, which compound in its .beta. glucoside form, corresponds with the formula ##STR1## It is notably useful for favoring immunitory responses relative to antigens of low immunogenicity.

REFERENCES:
patent: 4082735 (1978-04-01), Jones et al.
patent: 4082736 (1978-04-01), Jones et al.
F. Ellouz, et al., Biochem. and Biophysical Res. Communication 59, 1974, pp. 1317-1325.
Ghuysen et al., Bact. Membranes and Walls, 1973, pp. 39-41.
Chaturvedi, J. Med. Chem. 9, 1966, pp. 971-973.
Kotani et al., Sympos. Internat. or Bact. Immun. Stimulants, 1973, p. 8.
Lamzelotti et al., J. Am. Chem. Soc. 86, 1964, pp. 1880-1881.
Kotani et al., Biken J. 13, 105-111, 1975.
Adam et al., Biochem. and Biophys. Res. Comm. 72, 1976, pp. 339-346.
Chem. Abst. 87, 1977, pp. 199018m, 118075c, 51519e.

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