Immunoassay for phencyclidine

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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23230B, 260112B, 424 12, 546194, A61K 4300, G01N 3316

Patent

active

041961854

ABSTRACT:
An improved immunoassay for detecting the drug of abuse phencyclidine is described. This immunoassay is characterized in utilizing as reagents (i) an antibody elicited with a novel immunogen comprising 4-[(1-piperidinyl)cyclohexyl] benzoic acid covalently bonded to an immunogenic carrier material through the carboxyl group and (ii) a novel radiolabeled derivative of phencyclidine, namely .sup.125 I N-(4-hydroxy-2-phenylethyl)-4-[1-(1-piperidinyl)cyclohexyl] benzamide.

REFERENCES:
patent: 4000143 (1976-12-01), Dykstra et al.
patent: 4038268 (1977-07-01), Moritz et al.
Kaur et al., J. Med. Chem., vol. 12, 1969, pp. 473-476.
Kaur et al., Theriogenology, vol. 6, Nos. 2-3, 1976, pp. 193-208.
Pearce, Clin. Chem., vol. 22, No. 10, Oct. 1976, pp. 1623-1626.

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