Imidazothiazole derivatives and process for producing the same

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S303100

Reexamination Certificate

active

07662841

ABSTRACT:
The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1represents group —COR2wherein R2represents group OM or C1-12 alkyloxy wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal, or quaternary ammonium. The use of this compound as a synthetic intermediate can realize the production of carbapenem derivatives having potent antimicrobial activity in an efficient and safe manner at low cost.

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W. S. Huang et al., “Facile Synthesis of 1-Substituted 5-Trifluoromethylimidazole-4-Carboxylates”, Journal of Fluorine Chemistry, vol. 74, pp. 279-282, 1995.
R. I. Fryer et al., “The Synthesis of 4-H-Imidazol[5,1-c][1,4]benzothiazine Derivatives”, Journal of Heterocyclic Chemistry, vol. 20, No. 6, pp. 1605-1608, Nov.-Dec. 1983.

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