Imidazolium hydrogen carbonates

Details Imidazolium hydrogen carbonates Imidazolium hydrogen carbonates

1987-09-29

1989-02-28

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548354, 544139, 544370, 544129, 544130, 544 82, 544121, 544364, 544 60, 546210, 546187, C07D23366, C07D23304, C07D41300, C07D40300

Patent

active

048087270

ABSTRACT:
The pharmaceutically acceptable salts corresponding to the imidazolium hydrogen carbonates of the formula ##STR1## wherein the symbol Q is arylene or heteroarylene, the group --NR.sup.1 R.sup.2 is a basic amino group, R.sup.3 is hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, lower alkylthio, lower alkoxy or the group --(A).sub.n --Ra, R.sup.4 is a saturated or partially unsaturated lower hydrocarbon group, a basic amino group or the group --N.dbd.CRc--Rb, --CHRcRd, --NH--CHRcRd, --NH--CO--Re or --CHRc--CO--Re, R.sup.5 is hydrogen, lower alkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkyl, aryl or a fused benzene ring, R.sup.6 is hydrogen or lower alkyl, Ra and Rb each is aryl, heteroaryl or a basic amino group, Rc is hydrogen or lower alkyl, Rd is aryl or heteroaryl, Re is hydrogen, a saturated or partially unsaturated lower hydrocarbon group optionally attached via an oxygen atom or an aryl, heteroaryl or basic amino group optionally attached via a lower alkyl group, A is vinylene or lower alkylene, n is the integer 0 or 1 and the dotted line is an additional double bond, possess valuable antibacterial, antimycotic, protozoocidal and/or anthelmintic properties. The imidazolium bicarbonates of formula I can be used to prepare such pharmaceutically acceptable, especially water-soluble, salts in a simple and inexpensive manner.

REFERENCES:
patent: 3050520 (1962-08-01), Erner et al.
patent: 3577553 (1971-05-01), Feriauto
patent: 4025607 (1977-05-01), Stahle et al.
Bull. Chem. Soc. of Japan 51, 1846-1855 (1978).
Chem. Ber. 100, 3418-3426 (1967).
Chemical Abstracts 102, 59125x (1985).
Tetrahedron Letters 1978, 1295-1298.
Karpitschka, Eva Marie; Elektrophile N-Aminierung von Dimethylxanthinen and Einfachen Imidazolen. Funktionelle Derivate der N-Aminoverlindungen. Innsbruck 1981, Universitat, Dissertation.
Mussner, Renate; Ueber N-Aminoderivate von 2-Methylimidazolene. Innsbruck 1982, Universitat, Diplomarbeit.
Synthesis 1982, 592-594.
Chem. Pharm. Bull., 22, 482-484 (1974).
Chemical Abstracts 101, 2110040e (1984).

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