Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-03-25
1998-05-12
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483201, A61K 31415, C07D23384
Patent
active
057505527
ABSTRACT:
An imidazoline derivative or possible tautomer thereof, represented by the formula (1), wherein n represents one of integers "1" through "4", and R.sub.1 and R.sub.2 represent hydrogen atom, lower alkyl, aryl, aralkyl group, or R.sub.1 and R.sub.2 cooperate to represent alkylene, alkylidene or arylalkylidene group, while R.sub.3 represents a nitrogen-containing aromatic ring that may be substituted by lower alkyl, alkoxy or alkanoyl group, or a substituted phenyl group represented by the formula (2), wherein R.sub.4 and R.sub.5 represent hydrogen atom, lower alkyl group that may be substituted by halogen atom or hydroxyl group, cycloalkylalkyl group, lower alkenyl group, lower alkanoyl group that may be substituted by halogen atom, lower alkoxyalkyl or alkoxycarbonyl group, arylcarbonyl, arylalkyl or arylalkoxycarbonyl group, lower alkylaminocarbonyl or alkylsulfonyl group or arylsulfonyl group, or R.sub.4 and R.sub.5 cooperate with an adjacent nitrogen atom to constitute a cyclic structure, while R.sub.6 represents hydrogen atom, hydroxyl group, halogen atom, lower alkyl or alkoxy group or nitro group. ##STR1##
REFERENCES:
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4337257 (1982-06-01), Junggren et al.
patent: 4508905 (1985-04-01), Junggren et al.
patent: 5106863 (1992-04-01), Hajos et al.
Chemical and Pharmaceutical Bulletin, vol. 40, No. 3, 1992, Japan, pp. 675-682, Tomio Yamakawa et al., "Synthesis and Structure-Activity new class of gastric H+/K+-ATPase Inhibitors II".
Chemical and Pharmaceutical Bulletin, vol. 39, No. 7, 1991, Japan, pp. 1746-1752, Tomio Yamakawa et al.: "Synthesis and Structure-Activity a new class of gastric H+/K+ATPase inhibitors".
Arakawa Eitaro
Imai Keiji
Kato Tetsuo
Nakamura Yukitaka
Segami Tetsuya
Arax Co., Ltd.
Morris Patricia L.
LandOfFree
Imidazoline derivative, possible tautomer thereof, and vulnerary does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazoline derivative, possible tautomer thereof, and vulnerary, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazoline derivative, possible tautomer thereof, and vulnerary will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-979361