Imidazolidinedione derivatives and use thereof as drugs

Details Imidazolidinedione derivatives and use thereof as drugs Imidazolidinedione derivatives and use thereof as drugs

2005-07-19

2005-07-19

Powers, Fiona T. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S390000, C548S317100, C548S318500

Reexamination Certificate

active

06919365

ABSTRACT:
The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity[wherein R1and R2are the same or different, and denote a lower alkyl group or a phenyl group, or R1and R2are taken together to form a ring, R3denotes an optionally substituted naphthyl group or heterocyclic group, A denotes oxygen or NR4(R4is hydrogen or optionally substituted lower alkyl group), or NB2R5(R5is aryl group, and B2is carbonyl group or sulfonyl group), and B1denotes a carbonyl group or a sulfonyl group], or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5223523 (1993-06-01), Adams, Jr. et al.
patent: 780125 (1997-06-01), None
patent: 9-31061 (1997-02-01), None
Costanzo et al., Journal of Medicinal Chemistry, 46, 3865-3876, 2003.
Fukami et al., Current Pharmaceutical Design, 4, 439-453, 1998.
Rice et al., Current Pharmaceutical Design, 4, 381-396, 1998.
Takai et al., Current Vascular Pharmacology, 1, 217-224, 2003.
Niwata et al., Journal of Medicinal Chemistry, 40, 2156-2163, 1997.

Affiliated with

Also associated with

Rating

Imidazolidinedione derivatives and use thereof as drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazolidinedione derivatives and use thereof as drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazolidinedione derivatives and use thereof as drugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3385352