Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-03-15
1990-03-13
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514326, 514397, 514398, 544139, 546210, 548336, 548337, A61K 31415, C07D40104, C07D23388
Patent
active
049083635
ABSTRACT:
Imidazole derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2 each is lower alkyl, X is a residue of the formula ##STR2## R.sup.3 is hydrogen and R.sup.4 is hydrogen or lower alkyl or R.sup.3 and R.sup.4 taken together are an additional carbon-nitrogen bond; R.sup.5 is hydrogen or lower alkyl; R.sup.6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula --NR.sup.7 R.sup.8 ; and R.sup.7 and R.sup.8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.
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Klotzer Wilhelm
Montavon Marc
Mussner Renate
Singewald Nicolas
Gould George M.
Hoffmann-La Roche Inc.
Howard Mary Sue
Isgro William G.
Lee Mary C.
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