Imidazoindolizine derivatives process for preparation thereof an

Details Imidazoindolizine derivatives process for preparation thereof an Imidazoindolizine derivatives process for preparation thereof an

1992-09-03

1993-12-07

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, 5483021, A61K 31395, C07D47114, C07D51512, C07D51514

Patent

active

052683770

ABSTRACT:
An inidazoindolizine derivative of the formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is hydrogen, cyano, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl, lower alkylsulfonyl, substituted or unsubstituted phenyl, arylcarbonyl, or 5- or 6-membered nitrogen-containing heteromonocyclic group-substituted carbonyl, Ring A is substituted or unsubstituted phenyl, and m is 0 or 1, or a pharmaceutically acceptable salt thereof, and process for preparation thereof, said imidazoindolizine derivatives and pharmaceutically acceptable salts thereof show excellent angiotensin II inhibitory activities and are useful in the prophylaxis or treatment of hypertension.

REFERENCES:
patent: 4686226 (1987-08-01), Huff et al.
patent: 4816463 (1989-03-01), Blankley et al.
Wong et al., Cardiovascular Drug Reviews, vol. 9, No. 4, pp. 317-339 (1991).

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