Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1998-03-27
1999-09-28
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 946, 424 9466, 514 2, 514 12, 514 21, A61K 3848
Patent
active
059584076
ABSTRACT:
A method of treating or preventing post-operative ileus in a mammalian subject is disclosed. The method involves administering to the subject, a pharmaceutically effective amount of a compound that is effective in (i) preventing mast cell degranulation, (ii) inhibiting tryptase and chymase, and (iii) antagonizing PAR-2. The treatment is based on the discoveries that proteinase-activated receptor 2 is expressed in colonic muscle cells, and that activation of PAR-2 inhibits colonic motility. The PAR-2 receptor is activated, at least in part, by tryptase and chymase, produced by infiltration and degranulation of mast cells.
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Bunnett Nigel W.
Corvera Carlos U.
Channavajjala Lakshmi
Dehlinger Peter J.
Judge Linda R.
Page Thurman K.
The Regents of the Uinversity of California
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