Ikaros polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530350, 435 71, 435 691, 4352523, 4353201, 436503, A61K 3800

Patent

active

058247700

ABSTRACT:
A purified polypeptide having at least 85% sequence identity with an Ikaros polypeptide or exon.

REFERENCES:
Motnar et al. (1994) Molec-& Cell. Biol. 14:8292-8303.
Adams, B. et al. "Pax-5-encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis" Genes & Development 6: 1589-1607 (1992).
Akbar, A.N. et al. "A possible role for bcl-2 in regulating T-cell memory --a `balancing act` between cell death and survival" Immunology Today 14(11):526-531 (1993).
Ardavid, C. et al. "Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population" Nature 362: 761-763 (1993).
Asarnow, D.M. et al. "Limited Diversity of .gamma..beta. Antigen Receptor Genes of Thy-1.sup.+ Dendritic Epidermal Cells" Cell 55: 837-847 (2 Dec. 1988).
Beg, A.A. and A.S. Baldwin, Jr. "The IkB proteins: multifunctional regulators of Re/NF-kB transcription factors" Genes & Development 7: 2064-2070 (1993).
Bigby, M. et al. "Ratio of Langerhan Cells to Thy-1.sup.+ Dendritic Epidermal Cells in Murine Epidermis Influences the Intensity of Contact Hypersensitivity" The Journal of Investigative Dermatology 89(5): 495-499 (Nov. 1987).
Boise, L. et al. "bcl-x, a bcl-2-Related Gene that Functions as a Dominant Regulator of Apoptotic Cell Death" Cell 74: 597-608 (1993).
Bours, V. et al. "The Oncoprotein Bcl-3 Directly Transactivates through kB Motifs via Association with DNA-Binding p50B Homodimers" Cell 72: 729-739 (1993).
Cepko, C.L. et al. "Construction and Applications of a Highly Transmissible Murine Retrovirus Shuttle Vector" Cell 37: 1053-1062 (1984).
Clevers, H.C. et al. "Transcription factors in early T-cell development" Immunology Today 14(2): 591-596 (1993).
Connelly, C.S. et al. "The Role of Transgenic Animals in the Analysis of Various Biological Aspects of Normal and Pathologic States" Experimental Cell Research 183: 257-276 (1989).
Delwel, R. et al. Four of the Seven Zinc Fingers of the Evi-1 Myeloid-Transforming Gene Are Required for Sequence-Specific Binding to GA(C/T)AAGA(T/C)AAGATAA, Molecular and Cellular Biology 13(7): 4291-4300 (1993).
Ehlich, A. et al. "Immunoglobulin Heavy and Light Chain Genes Rearrange Independently at Early Stages of B Cell Development" Cell 72: 695-704 (1993).
Fife, A. et al. "Gram negative septicaemia diagnosed on peripheral blood smear appearances" Journal of Clinical Pathology 47: 82-84 (1994).
Fleming, W.H. et al. "Functional Heterogeneity Is Associated with the Cell Cycle Status of Murine Hematopoietic Stem Cells" J. Cell Biol. 122: 897-902 (1993).
Franzoso, G. et al "The oncoprotein Bcl-3 can facilitate NF-kB-mediated transactivation by removing inhibiting p50 homodimers from select kB sites" EMBO J. 12(10): 3893-3901 (1993).
Furley, A.J. et al. "Developmentally Regulated Rearrangement and Expression of Genes Encoding the T Cell Receptor-T3 Complex" Cell, vol. 46: 75-87 (Jul. 1986).
Garni-Wagner, B.A. et al. "Nature Killer Cells in the Thymus" Journal of Immunology 144(3): 796-803 (1990).
Georgopoulos, K. "Ikaros an Early Lymphoid Restricted Regulatory Protein a Putative Mediator for T Cell Specficiation" Biochem. Suppl. 0 (17 Part A): 158, B 631 (1993).
Georgopoulos, K. et al. "Functionally Distinct Isoforms of the CRE-BP DNA-Binding Protein Mediate Activity of a T-Cell-Specific Enhancer" Molecular and Cellular Biology 12(2): 747-757 (Feb. 1992).
Georgopoulos, K. et al. "Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment" Science 258: 808-812 (Oct. 1992).
Georgopoulos, K. et al. "A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-.delta. gene" EMBO J. 7(8): 2401-2407 (Aug. 1988).
Georgopoulos, K. et al. "Tissue-specific nuclear factors mediate expression of the CD3.delta. gene during T cell development" EMBO J. 9(1): 109-115 (Jan. 1990.).
Godfrey, D.I. and A. Zlotnik "Control points in early T-cell development" Immunology Today 14(11): 547-553 (1993).
Gogos, J. et al. "Sequence Discrimination by Alternatively Spliced Isoforms of a DNA Binding Zinc Finger Domain" Science 257: 1951-1955 (1992).
Hackett, Jr., J. et al. "Origin and Differentiation of Natural Killer Cells" Journal of Immunology 136(8): 3124-3131 (1986).
Hackett, Jr., J. et al. "Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes" Proc. Natl. Acad. Sci USA 83: 3427-3431 (1986).
Hardy, R.R. et al. "Resolution and Characterization of Pro-B and Pre-Pro-B Cell Stages in Normal Mouse Bone Marrow" J. Exp. Med. 173: 1213-1225 (May 1991).
Havran, W and J.P. Allision "Developmentally ordered appearance of thymocytes expressing different T-cells antigen receptors" Nature 335: 443-445 (1988).
Havran, W. and J.P. Allison "Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors" Nature 344: 68-70 (1990).
Havran, W. et al. "Limited diversity of T-cell receptor .gamma.-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V.gamma.3-specific monoclonal antibody" Proc. Natl. Acad. Sci. USA 86: 4185-4189 (1989).
Haynes, B.F. et al. "Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development" Immunology Today 10(3): 87-90(1989).
Hestdal, K. et al. "Characterization and Regulation of RB6-8C5 Antigen Expression on Murine Bone Marrow Cells" J. Immunol. 147(1): 22-28 (1 Jul. 1991).
Ho, I.-C. et al. "Human GATA-2: a lineage-restricted transcription factor that regulates the expression of the T cell receptor .alpha. gene" EMBO J. 10(5): 1187-1192 (1991).
Ho, I.-C. et al. "Sequence-Specific Binding of Human Ets-1 to the T Cell Receptor .alpha. Gene Enhancer" Science 250: 814-818 (1990).
Hsu, T. et al. "Multiple Zinc Finger Forms Resulting from Developmentally Regulated Alternative Splicing of a Transcription Factor Gene" Science 257: 1946-1950 (1992).
Ikuta, K. et al. "A Developmental Switch in Thymic Lymphocyte Maturation Potential Occurs at the Level of Hematopoietic Stem Cells" Cell 62: 863-874 (1990).
Ikuta, K. et al. "Lymphocyte Development From Stem Cells" Annu. Rev. Immunol. 10: 759-783 (1992).
Jiang, J. and M. Levine "Binding Affinities and Cooperative Interactions with bHLH Activators Delimit Threshold Responses to the Dorsal Gradient Morphogen" Cell 72: 741-752 (1993).
Juhlin, L. and W.B. Shelley "New Staining Techniques for the Langerhans Cell" Acta. Dermatovener. 57: 289-296 (1977).
Kang, S.-M. et al. "NF-kB Subunit Regulation in Nontransformed CD4.sup.+ T Lymphocytes" Science 256: 1452-1456 (1992).
Karasuyama, H. et al. "The Expression of V.sub.pre-B /.gamma.5 Surrogate Light Chain in Early Bone Marrow Precursor B Cells of Normal and B Cell-Deficient Mutant Mice" Cell 77: 133-143 (8 Apr. 1994).
Lagasse, E. and I.L. Weissman "BCL-2 Transgene Inhibits Neutrophils Cell Death But Not Their Engulfment By Microphages", J. Biochem. 0 (Suppl. 17D): 168 (13-31 Mar. 1993).
Leiden, J.M. et al. "Transcriptional regulation during T-cell development: The .alpha. TCR gene as a molecular model" Immunology Today 13(1): 22-30 (Jan. 1992).
Lenardo, M. and D. Baltimore "NF-kB: A Pleiotropic Mediator of Inducible and Tissue-Specific Gene Control" Cell 58: 227-229 (1989).
Li E. et al., "Targeted Mutation of the DNA Methyltransferase Gene Results in Embryonic Lethality" Cell 69: 915-926 (1992).
Li, Y.-S. et al. "The Regulated Expression of B Lineage Associated Genes during B Cell Differentiation in Bone Marrow and Fetal Liver" J. Exp. Med. 178: 951-960 (1993).
Liang, P. et al. "Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization" Nucleic Acids Research 21(14): 3269-3275 (1993).
Mann, R. et al. "Construction of a Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus" Cell 33: 153-159 (1993).
Martin, D.I.K. et al. "Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages" Nature 344: 444-447 (1990).
McDonnell, T.J. and S.J. Korsmeyer "Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic f

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ikaros polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ikaros polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ikaros polypeptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-245300

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.