Indolinones and pharmaceutical compositions containing same

Details Indolinones and pharmaceutical compositions containing same Indolinones and pharmaceutical compositions containing same

1984-07-27

1986-12-16

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546153, 546172, 546177, 546273, 548486, A61K 3140, C07D20934

Patent

active

046297332

ABSTRACT:
The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.

REFERENCES:
patent: 4329347 (1982-05-01), Muller et al.
patent: 4442111 (1984-04-01), Muller et al.
Chemical Abstracts, vol. 93, Abstract No. 220608q (1980).

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