Identification of M-CSF agonists and antagonists

Details Identification of M-CSF agonists and antagonists Identification of M-CSF agonists and antagonists

1995-06-05

2000-02-15

Ulm, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435375, 435 695, 4351723, 554211, 530351, 530412, 530418, 530419, 530421, G01N 3353

Patent

active

060251468

ABSTRACT:
The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.

REFERENCES:
Taylor et al 1994, J. Biol. Chem. 269,31171, 1994.
Pandit et al 1992 Science, 258, 1358, 1992.
Ollis et al (1990) (Meth. Enz. 182, 646), 1990.
McPherson (1982) (Preparation and Analysis of Protein Crystals John Wiley and Sons), 1982.

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