Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-03-22
2009-02-03
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S387100, C530S387900, C530S388150, C530S388240
Reexamination Certificate
active
07485431
ABSTRACT:
The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.
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patent: 2002/0006616 (2002-01-01), Gish et al.
patent: WO03/000012 (2003-01-01), None
patent: WO 03/002610 (2003-01-01), None
patent: WO03/004989 (2003-01-01), None
patent: WO 03/077875 (2003-09-01), None
Bahr, A., et al., “Homo sapiensCEGP1 protein (CEGP1), mRNA,” Nov. 2, 2000 (sequence) GenBank [online] Bethesda, MD, USA: National Center for Biotechnology Information [retrieved on Mar. 26, 2002]. GenBank Accession No. NM—020974.
Yang, Ruey-Bing, et al., “Identification of a novel family of cell-surface proteins expressed in human vascular endothelium,”The Journal of Biological Chemistry, vol. 277, No. 48 (Nov. 29, 2002) pp. 46364-46373.
Komuves Laszlo G.
Ng Chi Kin Domingos
Robison Keith E.
Tomlinson James E.
Topper James N.
Martinell James
Millennium Pharmaceuticals Inc.
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