Identification and characterization of inhibtors of protein farn

Details Identification and characterization of inhibtors of protein farn Identification and characterization of inhibtors of protein farn

1993-01-05

1996-11-26

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

424 945, C12N 910, A61K 3845

Patent

active

055784771

ABSTRACT:
A method of purifying protein farnesyltransferase (Ftase) uses recombinant technology and yeast host cells. Yeast farnesyltransferase purified by the method is useful in confirming specificity and kinetics of potential protein farnesyltransferase inhibitors. These inhibitors are useful for chemotherapy directed against cancers related to ras oncogenes.

REFERENCES:
patent: 5141851 (1992-08-01), Brown et al.
patent: 5420245 (1995-05-01), Brown et al.
Omer et al., Mol. Microbiol. 11:219-225 (1994).
Goodman, PH.D Thesis, Univ. Of Chicago, 1991, pp. 46-84.

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