Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1998-03-19
2000-09-26
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514456, 514783, 549403, A61K 3135, A61K 3578
Patent
active
061239445
ABSTRACT:
Icariin-containing preparations obtained from the aerial parts of a plant of the genus Epimedium, comprising about 15% to about 95% icariin by weight and about 5% to about 80% non-icariin flavones by weight. Also disclosed are methods of obtaining such preparations from an Epimedium plant.
REFERENCES:
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Coxam et al., "Effects of Dihydrotestosterone Alone and Combined with Estrogen on Bone Mineral Density, Bone Growth, and Formation Rates in Ovariectomized Rats", (1996) 19(2):107-114.
Dempster et al., "Temporal Changes in Cancellous Bone Structure of Rats Immediately After Ovariectomy", Bone (1995) 16(1):157-161.
Marsili et al., "Comparison of a Liquid Solvent Extraction Technique and Supercritical Fluid Extraction for the Determination .alpha. and .beta.-Carotene in Vegetables", Cromatogr. Sci. (1983) 31:422-428.
Wronski et al., "Time Course of Vertebral Osteopenia in Ovariectomized Rats", Bone (1989) 10:295-301.
Yamazaki et al., "Effect of Ipriflavone on Glucocorticoid-Induced Osteoporosis in Rats", Life Sciences, (1986) 38:951-958.
Yingjie et al., "Studies of the Biologically Active Constituents of Epimedium Koreanum Nakai", Process in Drug Development from Medicinal Plants, Proceeding of UNESCO Regional Symposium on Drug Development from Medicinal Plants, Oct. 25-17, 1996, Hangzhou, China, organized by Shanghai Institute of Materia Medica, et al., in cooperation with United Nations Educational, Scientific and Cultural Organization.
Chen Ying Jie
Kung Patrick C.
PhytoCeutica, Inc.
Webman Edward J.
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