ICAM-1/LFA-1 short-chain peptides and method of using same

Details ICAM-1/LFA-1 short-chain peptides and method of using same ICAM-1/LFA-1 short-chain peptides and method of using same

1996-11-19

1999-01-26

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 530300, 530350, 530324, 530325, 530326, A61K 3802, C07K 1400, C07K 704

Patent

active

058638890

ABSTRACT:
Short-chain peptides replicating fragments of functional domains derived from LFA-1 and ICAM-1 parent protein sequences serve to modulate the ICAM/LFA binding interaction. In one aspect of the invention, this modulation serves to block interprotein binding reactivity, as a peptide of the invention binds to a target protein in a manner that precludes the normal binding reaction between ICAM-1 and LFA-1. In another aspect of the invention, this modulation enhances the reactivity of a first peptide, as a second peptide induces a conformational change in the target protein from a first conformation to a second, more reactive, conformation. The peptides are used according to a method including the steps of providing the proteins and applying them to a population of cells.

REFERENCES:
patent: 5340800 (1994-08-01), Lin et al.
Hynes, Cell 69, 11-25, 1992.
Stanley et al. EMBO J. 13, 1790-1798, 1994.

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