IAPS associated cell cycle proteins, compositions and...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07423118

ABSTRACT:
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

REFERENCES:
patent: 6066474 (2000-05-01), Marcu
patent: 97/21809 (1997-06-01), None
patent: 98/44102 (1998-10-01), None
Salvesen et al (Nature Reviews Molecular Cell Biology, 2002, 3:401-410).
Alberts et al (Molecular Biology of the Cell, 3rd ed., 1994, p. 465).
Shantz and Pegg (Int. J. Biochem and Cell Biol., 1999, 31:107-122).
McClean and Hill (Eur J Can., 1993, 29A, pp. 2243-2248).
Fu et al (Embo J. 1996, 15:4392-4401).
Tam et al (Cancer Research, 1998, 58:5315-5320).
Van de Craen et al (Y 13086), Genbank Sequence Database, national Center for Biotecnology Information, National Library of Medicine, Bethesda, Maryland, publicly available, 1997).
Van de Creaen et al (Y13088) Genbank Sequence Database, national Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, publicly available, 1997).
Szak et al (Mol. Cel. Biol., 21:2001, 3375-3386).
Garkavstev et al., “Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation,”Nat. Genet., 23(3):373 (Nov. 1999).
Jäger, et al., “Cancer-Testis Antigens andING1Tumor Suppresor Gene Product Are Breast Cancer Antigens: Characterization of Tissue-specificING1Transcripts and a Homologue Gene,”Cancer Res59:6197-6204 (Dec. 1999).
Liston et al., Suppression of Apoptosis in Mammalian Cells by NAIP and a Related Family of IAP Genes, Nature, 1996, 379(6563): 349-53 (abstract only).
McCarthy et al., “Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs),”J. Biol. Chem., 273(37):24009-24015 (1998).
Helbing et al., “A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis,”Cancer Res., 57(7):1255-1258 (1997).
Garkavstev et al., “Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation,”Nat. Genet., 14(4):415-420.
Garkavstev et al., “The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control,”Nature, 391(6664):295-298 (1998).
Shimada et al., “Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor,”Cytogenet. Cell Genet., 83(3-4):232-235 (1998).
Vucic et al., “Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM,”Mol. Cell. Biol., 18(6):3300-3309 (1998).
Kaiser et al., “Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs),”Proc. Natl. Acad. Sci. USA, 94(19):10183-10188 (1997).
Hay et al., “Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death,”Cell, 83(7):1253-1262 (1995).
Avdonin et al., “Apoptotic proteins Reaper and Grim induced stable inactivation in voltage-gated K + channels,”Proc. Natl. Acad. Sci.USA, 95(20):11703-11708 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

IAPS associated cell cycle proteins, compositions and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with IAPS associated cell cycle proteins, compositions and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and IAPS associated cell cycle proteins, compositions and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3988312

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.