Hypolipidemic agents

Details Hypolipidemic agents Hypolipidemic agents

1975-06-16

1977-04-12

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602471P, 2602472R, 260268H, 260290R, 26029357, 26032682, 260329HS, 2603323R, 424250, 424263, 424267, 424275, C07D33324

Patent

active

040175146

ABSTRACT:
Substituted thiophenecarboxylic acids and esters and pharmaceutically acceptable salts thereof of the following general structure are useful as hypolipidemic agents: ##STR1## wherein R is selected from a straight or branched saturated hydrocarbon chain containing from 10 to 20 carbon atoms and a straight or branched unsaturated hydrocarbon chain containing from 10 to 20 carbon atoms and from 1 to 4 double bonds; R.sub.1 is selected from hydrogen, a straight or branched lower alkyl chain of from 1 to 6 carbon atoms, benzyl, phenethyl, pyridyl-methyl, alkane-poly-yl containing from 3 to 6 carbon atoms, 1,2,3,4,5,6-cyclohexanehexayl, and Z; Z is selected from ##STR2## wherein n is the integer 2 or 3; R.sub.2 is selected from a straight or branched lower alkyl chain of from 1 to 4 carbon atoms, and alkylcarbonyl wherein the alkyl moiety contains from 1 to 4 carbon atoms and may be straight or branched; R.sub.3 is selected from hydrogen and a straight or branched lower alkyl chain of from 1 to 4 carbon atoms with the proviso that when R.sub.3 is hydrogen, R.sub.2 is alkylcarbonyl; or when R.sub.2 is other than alkylcarbonyl, R.sub.2 and R.sub.3 taken together with the nitrogen atom to which each is attached form a monocyclic heterocyclic group selected from pyrrolidino, piperidino, morpholino, and piperazino; or ##STR3## wherein the sum of the integers m and p is equal to from 3 to 5; and R.sub.4 is a straight or branched lower alkyl chain of from 1 to 4 carbon atoms; X is an integer of from 1 to 6 with the proviso that when R.sub.1 is alkane-poly-yl or 1,2,3,4,5,6-cyclohexanehexayl, X is equal to from 2 to 6, and when R.sub.1 is other than alkane-poly-yl or 1,2,3,4,5,6-cyclohexanehexayl, X is equal to 1.

REFERENCES:
jakobsen et al. "Chem. Abst." (1964) vol. 60, pp. 6808c-6809b.

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